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| TITLE: |
Safety of glutamine-enriched parenteral
nutrient solutions in humans. |
| AUTHORS: |
Lowe DK; Benfell K; Smith RJ; Jacobs
DO; Murawski B; Ziegler TR; Wilmore DW |
| AUTHOR AFFILIATION: |
Department of Surgery, Harvard Medical
School, Brigham and Women's Hospital, Boston, MA 02115. |
| SOURCE: |
Am J Clin Nutr 1990 Dec;52(6):1101-6 |
| CITATION IDS: |
PMID: 2122714 UI: 91051341 |
| ABSTRACT: |
To determine the safety of glutamine-enriched
parenteral nutrition, seven normal volunteers were admitted to the Clinical
Research Center for three 5-d study periods. The subjects received infusions
of parenteral nutrients containing increasing doses of glutamine (0, 0.285,
and 0.570 g.kg body wt-1.d-1) substituted for alanine and glycine. Each
study period was preceded by greater than or equal to 2 wk of normal food
intake. The diets were isocaloric (1.2X estimated basal metabolic rate)
and isonitrogenous (1.5 g protein.kg-1.d-1) with nonprotein calories given
as dextrose (38%) and fat emulsion (62%). The diets were all well tolerated
and there were no untoward effects. Plasma glutamine concentrations increased
significantly with glutamine administration but plateaued at concentrations
approximately 25% above control values. Ammonia and glutamate, potentially
toxic metabolites of glutamine, did not change significantly with glutamine
enrichment. Nitrogen balance and hormonal concentrations were unchanged
during the three dietary periods. Results of mental-status examinations
and continuous performance testing were normal and unchanged throughout
the three periods. Glutamine-enriched parenteral nutrient solutions are
well tolerated with no associated signs of toxicity in normal humans. |
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