[Study 1]

Initial studies in normal individuals evaluated the short-term response to oral loads of glutamine at doses of 0, 0.1, and 0.3 g/kg. 

[That's a 7.5g or 22.5g ORAL dose for an average 75kg person.  Way more than the 2g I use..GW]

A dose-related increase in blood glutamine occurred after oral loading and elevation of amino acids known to be end products of glutamine metabolism occurred (including alanine, citrulline, and arginine). 

No evidence of clinical toxicity or generation of toxic metabolites (ammonia and glutamate) was observed. 

[>>>>>> Please note that this study found NO increase in Glutamate levels even after a 22.5g ORAL dose <<<<<]

[Study 2]

Glutamine was infused intravenously in normal subjects over 4 hr at doses of 0.0125 and 0.025 g/kg/hr. 

[Study 3]

In addition, glutamine was evaluated as a component of parenteral nutrition solutions (0.285 and 0.570 g/kg/day) administered for 5 days to normal subjects. 

Intravenous administration of glutamine was well tolerated without untoward clinical or biochemical effects. 

[Again NO increased Glutamate production]

Subsequent studies in patients receiving glutamine-enriched parenteral nutrition for several weeks confirmed the clinical safety of this approach in a catabolic patient population. 

In addition, nitrogen retention appeared to be enhanced when glutamine was administered at a dose of 0.570 g/kg/day in a balanced nutritional solution providing adequate calories (145% of basal) and protein (1.5 g/kg/day). 

[Here the research team added 42.75g to meals over a day.  I would never injest that much Glutamine]

Nitrogen balance in patients receiving lower doses of glutamine (0.285 g/kg/day) was similar to that in patients receiving standard formulations. 

Further controlled clinical trials of the metabolic efficacy, tolerance, and dose response of glutamine in other patient groups are necessary to determine the appropriate use of glutamine enrichment of nutrient solutions.

[Note that the further trials are suggested for Glutamine enriched nutrient solutions (Study 3).  The data from Study 1 & Study 2 is accepted as fact]