Growth Hormone, DHEA & Menopause

WHAT IS MENOPAUSE?

This term refers to the cessation of menstruation as a result of slowed estrogen production. It includes a sometimes lengthy period of time, beginning between the ages of 45 and 55, when menstruation becomes irregular and the production of female sex hormones goes through periodic fluctuations in intensity and quality.

Eventually, the follicles cease to release eggs, which leads to a decrease in estrogen production. Without the influence of estrogen, an increase in the level of gonodotropin hormones and androgens may occur.

More than half of menopausal women experience hot flashes and night sweats.  These symptoms may last up to five or more years.  Over 20 percent experience significant vaginal dryness.  In all women, the vagina itself will shrink and lose elasticity and become more susceptible to infection.  The breasts sag and the skin will lose its softness.

The result might be a variety of unsettling physiological and psychological symptoms:

One of the most troublesome aspects of menopause is the loss of calcium from the bones.  Over time this can lead to severe osteoporosis.  Menopause may also produce an increased risk of hypertension and sclerosis, and increase the risk of stroke or coronary heart disease.
 

PROGESTERONE & MENOPAUSE

Hormone therapy using synthetic progesterone or progestins and synthetic estrogen (which is made from the urine of pregnant horses), is widely prescribed for menopausal therapy.

In spite of all of the known side effects and risks associated with taking these synthetic analogs, most doctors continue to prescribe them.  Instead of helping, these synthetic analogs often aggravate symptoms causing irritability and emotional problems.

While estrogen has shown to have beneficial cardiovascular effects, progestins exerts a detrimental effect on blood lipids by increasing LDL and reducing HDL cholesterol.
 

POTENTIAL SIDE EFFECTS OF SYNTHETIC PROGESTERONE:

With the onset of menopause women experience the increased risk for development of osteoporosis.  For years synthetic hormones have been recommended. But, John Lee, M.S., in his 1993 book, Natural Progesterone states that not only can natural progesterone serve as a prevention for osteoporosis, it can actually reverse it.  He used a transdermal application of DHEA and proved that osterporosis is reversible in almost 100 percent of the cases he followed.  This was without the use of dangerous synthetic estrogens that increase the risk of breast, endometrial cancers, and other diseases.
 

HORMONE REPLACEMENT THERAPY (HRT)

Many women resort to hormone replacement therapy (HRT) with synthetic estrogens to help counteract menopausal changes.  The side effects from these drugs can be very unpleasant.  Breast tenderness, bloating, weight gain, nausea, reduced sex drive, depression, headaches, and vaginal bleeding are common.  They also increase risk for blood clots which could precipitate stroke and increase hypertension.

Many post menopausal women do not need estrogen supplements.  Not only does a woman's body continue to produce some estrogen but she is ingesting phytoestrogens (estrogenic substances found in plants) and is exposed to xenoestrogens (environmental estrogenic substances of petrochemical origin).  The addition of progesterone enhances the receptors of estrogen and thus her need for estrogen may not exist.

Hot flashes are not a sign of estrogen deficiency, but are due to heightened hypothalamic activity due to low levels of progesterone and estrogen.  If these levels were raised, a negative feedback message is sent to the pituitary and hypothalamus.  Once progesterone levels are raised, estrogen receptors become more sensitive, and hot flashes usually subside.
 

ESTROGENS

There is no specific hormone named estrogen.  Estrogen is the name for a class of female steroid hormone compounds of which there are 20 or so members.  The major estrogens are estrone (E-1), estradiol (E-2), and estriol (E-3).

Estrogens aid the development of secondary female sex traits such as breast development and fat deposited under the skin.  Estrogen deficiency and amenorrhea (absence of monthly menstrual flow) have many causes including prolactin-producing tumours, anorexia nervosa, intense exercise associated with leanness, as well as natural or surgical menopause.

Estrogens are associated with procreation and survival of the foetus, as it is advantageous to the baby for the expectant mother to be able, in times of famine, to store body fat.  Thus, the effects of estrogen include far more than merely its action on creating the female body from and its stimulation of the uterus and breasts.  During times of consistent dietary abundance (especially excess fat in the diet), estrogen's effects are potentially undesirable.
 

POTENTIAL SIDE EFFECTS OF SYNTHETIC ESTROGEN

Supplemental estrogen is used in oral contraceptives to treat post menopausal breast cancer and prostate cancer and to inhibit the production of breast milk.  It is also used to prevent miscarriage, and treat osteoporosis the ovarian disease.

Although many physicians recommend estrogen replacement for post menopausal and post hysterectomy women, it is generally agreed that the detrimental health risks out weights the benefit in most women at risk for osteoporosis.

Ads for Premarin brand of conjugated estrogen tablets can be found in many women's and health magazines.  They market to women concerned about osteoporosis and menopause.  Premarin is described as a complex blend of estrogens manufactured by a 125-step, 6 week process.  Something that requires so much processing seems far from anything natural and beneficial to the body.
 

POTENTIAL SIDE EFFECTS OF SYNTHETIC HORMONES LIKE PREMARIN

Many of synthetic estrogen's undesirable side effects are effectively prevented by progesterone.  It is the custom of contemporary medicine to prescribe estrogen alone for women without intact uteri and , equally unfortunate, pre menopausal estrogen dominance is simply ignored.

During the 1970's it became obvious that post menopausal women taking unopposed estrogen for hot flashes, prevention of osteoporosis, etc., were at increased risk of endometrial cancer.  This type of cancer is an uncommon occurrence before menopause when one has normal levels of estrogen and progesterone.  Combined hormone therapy (using both estrogen and a progestin) in post menopausal women can reduce the risk of estrogen-induced endometrial cancer.

Remember that there are many additional hormones in the body besides estrogens and progesterone.  Any time a synthetic hormone is introduced to the body, the hormonal balance (homeostasis) of the body is upset.  Problems, which are referred to as side effects, are then the result of this imbalance.  One can attempt to balance estrogen and progesterone, helping to eliminate some potential problems, but there are dozens of other hormones to also be concerned with.

The bottom line is once you start messing with the hormonal balance of the male or female body by introducing a synthetic hormone, you cannot avoid the break down of homeostasis (hormone balance) and the related negative side effects.
 

NATURAL HORMONE REPLACEMENT THERAPY & DHEA

Menopause is associated with a reduction in DHEA levels.  In one study, the average plasma level of DHEA was 542 in pre menopausal women, 197 in post menopausal women, and only 126 in a post hysterectomy women.  In a group of women between the ages of 55 and 85 years, there was a significant correlation between serum levels of DHEA-S and bone density of the vertebral spine.  Women with higher levels of DHEA had greater bone mass than those with lower DHEA levels.

In young females, the ovaries are responsible for 50 percent of androgen production and the remainder coming from conversion of DHEA with-in other tissues.  With aging, the ovary, despite estrogen loss, is still able to synthesize androgens.  However, clinical estrogen substitution does nothing to restore DHEA levels, suggesting a non-estrogen dependent role for ovarian function in regulating DHEA production.  Removal of the ovaries has shown to have a significant influence on DHEA levels enhancing the age related decline. However, DHEA decline is probably indicative of changes in the adrenals. The implications of this suggests that the other androgens whose levels are fairly stable despite aging may have more psychological importance to the maintenance of youthful survival which ay go beyond their role as sex steroids.

As APGL has been shown to increase DHEA via increased IGF-1 & Growth Hormone levels, its seems clear that APGL will increase NATURAL estrogen levels while allowing the body to stay in its hormone balance state (homeostasis) and enjoy the additional benefits derived from increased natural GH.

The APGL to Estrogen (Anti-Menopausal) link.

POST MENOPAUSAL HORMONE REPLACEMENT THERAPY

A recent study in post menopausal women concluded that DHEA benefits estrogen therapy.  DHEA protects against neoplasia, osteoporosis, and cardiac disease, and DHEA should be effective in treating the decline in function due to menopause.

Supplemental DHEA given orally has proven to be highly beneficial.  Healthy women given DHEA rapidly convert it to estrogens causing a 300-500 percent temporary increase in levels.  Testosterone levels also temporarily increase.  These effects occur ONLY if the body naturally requires such a conversion.

Supplemental DHEA or Natural DHEA via APGL is non-toxic and far safer than taking synthetic hormones or steroids.